Molecular Modeling And Simulation

Author: Tamar Schlick
Publisher: Springer Science & Business Media
ISBN: 9780387224640
Size: 19.99 MB
Format: PDF, Kindle
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Very broad overview of the field intended for an interdisciplinary audience; Lively discussion of current challenges written in a colloquial style; Author is a rising star in this discipline; Suitably accessible for beginners and suitably rigorous for experts; Features extensive four-color illustrations; Appendices featuring homework assignments and reading lists complement the material in the main text

Molecular Modeling And Simulation An Interdisciplinary Guide

Author: Tamar Schlick
Publisher: Springer Science & Business Media
ISBN: 1441963510
Size: 16.98 MB
Format: PDF, ePub
View: 96

Very broad overview of the field intended for an interdisciplinary audience; Lively discussion of current challenges written in a colloquial style; Author is a rising star in this discipline; Suitably accessible for beginners and suitably rigorous for experts; Features extensive four-color illustrations; Appendices featuring homework assignments and reading lists complement the material in the main text

Dynamic Systems Biology Modeling And Simulation

Author: Joseph J. DiStefano
Publisher: Academic Press
ISBN: 0124104118
Size: 14.24 MB
Format: PDF, ePub, Docs
View: 59

Dynamic Systems Biology Modeling and Simuation consolidates and unifies classical and contemporary multiscale methodologies for mathematical modeling and computer simulation of dynamic biological systems - from molecular/cellular, organ-system, on up to population levels. The book pedagogy is developed as a well-annotated, systematic tutorial - with clearly spelled-out and unified nomenclature - derived from the author's own modeling efforts, publications and teaching over half a century. Ambiguities in some concepts and tools are clarified and others are rendered more accessible and practical. The latter include novel qualitative theory and methodologies for recognizing dynamical signatures in data using structural (multicompartmental and network) models and graph theory; and analyzing structural and measurement (data) models for quantification feasibility. The level is basic-to-intermediate, with much emphasis on biomodeling from real biodata, for use in real applications. Introductory coverage of core mathematical concepts such as linear and nonlinear differential and difference equations, Laplace transforms, linear algebra, probability, statistics and stochastics topics; PLUS ... The pertinent biology, biochemistry, biophysics or pharmacology for modeling are provided, to support understanding the amalgam of "math modeling" with life sciences. Strong emphasis on quantifying as well as building and analyzing biomodels: includes methodology and computational tools for parameter identifiability and sensitivity analysis; parameter estimation from real data; model distinguishability and simplification; and practical bioexperiment design and optimization. Companion website provides solutions and program code for examples and exercises using Matlab, Simulink, VisSim, SimBiology, SAAMII, AMIGO, Copasi and SBML-coded models.

Computer Simulation Methods In Theoretical Physics

Author: Dieter Heermann
Publisher: Springer Science & Business Media
ISBN: 9783642969713
Size: 13.39 MB
Format: PDF, ePub
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Appropriately for a book having the title "Computer Simulation Methods in Theoretical Physics", this book begins with a disclai mer. It does not and cannot give a complete introduction to simu lational physics. This exciting field is too new and is expanding too rapidly for even an attempt to be made. The intention here is to present a selection of fundamental techniques that are now being widely applied in many areas of physics, mathematics, chem istry and biology. It is worth noting that the methods are not only applicable in physics. They have been successfully used in other sciences, showing their great flexibility and power. This book has two main chapters (Chaps. 3 and 4) dealing with deterministic and stochastic computer simulation methods. Under the heading "deterministic" are collected methods involving classical dynamics, i.e. classical equations of motion, which have become known as the molecular dynamics simulation method. The se cond main chapter deals with methods that are partly or entirely of a stochastic nature. These include Brownian dynamics and the Monte Carlo method. To aid understanding of the material and to develop intuition, problems are included at the end of each chapter. Upon a first reading, the reader is advised to skip Chapter 2, which is a general introduction to computer simUlation methods.

Linear Algebra Through Geometry

Author: Thomas Banchoff
Publisher: Springer Science & Business Media
ISBN: 0387975861
Size: 14.23 MB
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This book introduces the concepts of linear algebra through the careful study of two and three-dimensional Euclidean geometry. This approach makes it possible to start with vectors, linear transformations, and matrices in the context of familiar plane geometry and to move directly to topics such as dot products, determinants, eigenvalues, and quadratic forms. The later chapters deal with n-dimensional Euclidean space and other finite-dimensional vector space.

Molecular Modelling

Author: Andrew R. Leach
Publisher: Pearson Education
ISBN: 0582382106
Size: 13.14 MB
Format: PDF, Kindle
View: 15

Useful concepts in molecular modelling. An introduction to computational quantum mechanics. Advanced ab initio methods, density functional theory and solid-state quantum mechanics. Empirical force field models: molecular mechanics. Energy minimisation and related methods for exploring the energy surface. Computer simulation methods. Molecular dynamics simulation methods. Monte Carlo simulation methods. Conformational Analysis. Protein structure prediction, sequence analysis and protein folding. Four challenges in molecular modelling: free energies, solvation, reactions and solid-state defects. The use of molecular modelling and chemoinformatics to discover and design new molecules.

Handbook Of Detection Of Enzymes On Electrophoretic Gels

Author: Gennady P. Manchenko
Publisher: CRC Press
ISBN: 1420040537
Size: 18.14 MB
Format: PDF, ePub, Docs
View: 86

Still widely used as gene markers, isozymes detected by zymogram techniques have proven valuable in a range of other biological applications over the last few years. Along with these new applications, many new techniques have also emerged. Yet more than eight years since the Handbook of Detection of Enzymes on Electrophoretic Gels was first published, it remains the only book completely devoted to zymogram methods. The time has come to bring its contents up to date. New in the Second Edition: An overview of new applications of enzyme electrophoresis and zymogram techniques Zymogram techniques for approximately 100 enzymes not included in the first edition, bringing the total to more than 900 methods for detecting more than 400 different enzymes Information on subunit structure included within the enzyme sheets to facilitate interpretation of isozyme patterns detected on zymograms An appendix containing information on the buffer systems most commonly used for enzyme electrophoresis in starch, cellulose acetate, and polyacrylamide gels. The second edition of this bestselling handbook makes significant additions to the set of reliable gene markers suitable for electrophoretic analysis. It also strengthens the value of enzyme electrophoresis as a powerful tool proven successful in solving a variety of problems encountered across many biological areas, including the post-genome biology.